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Organization of the biosynthetic gene cluster for the polyketide macrolide mycinamicin in<i>Micromonospora griseorubida</i>

1 Jan 2003

Abstract excerpt

Mycinamicin, composed of a branched lactone and two sugars, desosamine and mycinose, at the C-5 and C-21 positions, is a 16-membered macrolide antibiotic produced by Micromonospora griseorubida A11725, which shows strong antimicrobial activity against Gram-positive bacteria. The nucleotide sequence (62 kb) of the mycinamicin biosynthetic gene cluster, in which there were 22 open reading frames (ORFs), was...

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PMID: 12583909
DOI: 10.1111/j.1574-6968.2003.tb11509.x

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