Article

Neuronal Hyperactivity in Neurons Derived from Individuals with Grey Matter Heterotopia

2024-07-10

Abstract excerpt

Periventricular heterotopia (PH), a common form of grey matter heterotopia associated with developmental delay and drug-resistant seizures, poses a challenge in understanding its neurophysiological basis. Human cerebral organoids (hCOs) derived from patients with causative mutations in FAT4 or DCHS1 mimic PH features. However, neuronal activity in these 3D models has not yet been invetigated. Here, silicon probe...

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Literature Corpus work: a024240b-581b-5d5a-bf54-74e8f16caf88
DOI: 10.1101/2024.07.10.602948

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