Article

Intrinsic and extrinsic mechanisms alter neural cell fate specification in EPM1 Epilepsy

2024-11-21

Abstract excerpt

The extracellular milieu, including extracellular vesicles (EVs), plays a pivotal role in brain development by regulating neural processes such as proliferation, differentiation, and migration. In this study, we sought to elucidate the pathogenesis of progressive myoclonus epilepsy type 1 (EPM1), a disease caused by mutations in the CSTB gene, using cerebral organoids (COs) derived from EPM1 patient cells. The re...

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Literature Corpus work: 3bfb945d-b790-50a9-a9e0-1323cfac39f6
DOI: 10.1101/2024.11.20.624470

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