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Article

Shaping immune landscape of colorectal cancer by cholesterol metabolites

2 Jan 2024

Abstract excerpt

Cancer immunotherapies have achieved unprecedented success in clinic, but they remain largely ineffective in some major types of cancer, such as colorectal cancer with microsatellite stability (MSS CRC). It is therefore important to study tumor microenvironment of resistant cancers for developing new intervention strategies. In this study, we identify a metabolic cue that determines the unique immune landscape of...

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PMID: 38177537
DOI: 10.1038/s44321-023-00015-9

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