Article
AKR1B10 reprograms neutrophils by histone lactylation to foster immune evasion in KRASG12C mutation colorectal cancer liver metastasis.
Journal of experimental & clinical cancer research : CR - 3 Feb 2026
Li Weiwei, Yuan Wenkang, Du Zihao, Wang Xiangyu, Wang Daoyue, Xing Songlin, Shen Tingting, Lu Canliang, Chen Jiale, Yu Anhai, Jiang Xinyu, Zhang Shiwei, Zheng Shuhao, Feng Xiaowen, Wang Tianqi, Zuo Jieliang, Chen Jinhong, Zhang Chao, Wang Xuefu, Zhang Chong
Abstract excerpt
BACKGROUND: The KRASG12C mutation is one of the special mutation types in patients with colorectal cancer liver metastasis (CRLM). Although several small molecule inhibitors specifically targeting KRASG12C mutation have been developed, they have only shown limited clinical benefits for CRLM patients. Thus, alternative approaches are still needed. METHODS: We screened out the differentially expressed gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.