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Article

Early alteration of the locus coeruleus in phenotypic variants of Alzheimer’s disease

23 Jun 2019

Abstract excerpt

Neuropathological studies showed early locus coeruleus (LC) neuronal loss associated with tauopathy in Alzheimer's Disease (AD). We used the LC signal intensity (LC-I) on 3T MRI to assess the LC integrity in AD (n = 37) and controls (n = 17). The LC-I was decreased in AD regardless of typical (amnesic) and atypical presentation (logopenic aphasia/visuo-spatial deficit), from the prodromal stage, and independently...

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PMID: 31353860
DOI: 10.1002/acn3.50818

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