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Article

Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jun 2026

Koops Elouise A, Giudicessi Averi, Baena Ana, Martinez Lusiana, Bonillas-Felix Nikole, Medrano Randy, Dutta Joyita, Gonzalez Isabela, Alvarez Sergio, Aguillon David, Quiroz Yakeel T, Jacobs Heidi I L

Abstract excerpt

INTRODUCTION: Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC-entorhinal cortex (LC-EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD). METHODS: We examined associations between diffusion-weighted imaging-derived LC-EC tract characteristics and age, sex, amyloid...

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PMID: 42273784
DOI: 10.1002/alz.71587
PMCID: PMC13254689

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PSEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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