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Article

Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2023

Jacobs Heidi I L, Becker John Alex, Kwong Kenneth, Munera Diana, Ramirez-Gomez Liliana, Engels-Domínguez Nina, Sanchez Justin S, Vila-Castelar Clara, Baena Ana, Sperling Reisa A, Johnson Keith A, Lopera Francisco, Quiroz Yakeel T

Abstract excerpt

INTRODUCTION: Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored. METHODS: We associated LC integrity (3T-MRI) with...

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PMID: 35298083
DOI: 10.1002/alz.12656
PMCID: PMC9481982

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