Article

Single nucleus sequencing fails to detect microglial activation in human tissue

2020-04-13

Abstract excerpt

Single nucleus RNA-Seq (snRNA-Seq) methods are used as an alternative to single cell RNA-Seq methods, as they allow transcriptomic profiling of frozen tissue. However, it is unclear whether snRNA-Seq is able to detect cellular state in human tissue. Indeed, snRNA-Seq analyses of human brain samples have failed to detect a consistent microglial activation signature in Alzheimer’s Disease. A comparison of microglia...

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Literature Corpus work: e4323aa1-b9eb-50df-98fb-bf830c80861d
DOI: 10.1101/2020.04.13.035386

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