Article

Lanifibranor (IVA-337) - a pan-PPAR agonist suppresses TGF-β1-induced cardiac fibrosis and rescues cardiomyocyte function

2026-08-21

Abstract excerpt

<h4>Background: </h4> Cardiac fibrosis is a hallmark of many cardiovascular diseases, driven by sustained fibroblast activation and excessive extracellular matrix deposition, leading to myocardial stiffening and impaired contractility. Current therapies inadequately address this process. This study evaluated the antifibrotic potential of lanifibranor, a balanced pan-peroxisome proliferator-activated receptors (PPA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e41632af-1a1a-57e5-9343-a1c3a6695b47
DOI: 10.64898/2026.08.18.745414

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lanifibranor (IVA-337) - a pan-PPAR agonist suppresses TGF-β1-induced cardiac fibrosis and rescues cardiomyocyte functionDOI 10.64898/2026.08.18.745414Read

The dual PPAR-α/δ agonist elafibranor attenuates TGF-β <sub>1</sub> -induced cardiac fibrosis through redox-metabolic and bioenergetic reprogramming in human cardiac modelsSemantic proximity Read

Repurposing Nintedanib for Pathological Cardiac Remodeling and DysfunctionSemantic proximity Read

Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac FibroblastsSemantic proximity Read

Psoralen Enhances Direct Cardiac Reprogramming via PPARα Activation and Promotion of Mitochondrial FissionSemantic proximity Read

Single-nuclear transcriptome profiling identifies persistent fibroblast activation in hypertrophic and failing human hearts of patients with longstanding diseaseSemantic proximity Read

Consequences of PDGFRα <sup>+</sup> fibroblast reduction in adult murine heartsSemantic proximity Read

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failureSemantic proximity Read

Adipocyte Enhancer Binding Protein 1 (AEBP1) Inhibition as a Potential Anti-Fibrotic Therapy in Heart Failure.Semantic proximity Read

Myocardial fibroblast–matrix interactions and potential therapeutic targetsSemantic proximity Read

Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism.Semantic proximity Read

Molecular Profiling Reveals a Common Metabolic Signature of Tissue FibrosisSemantic proximity Read

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the HeartSemantic proximity Read