Article
Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a β-Adrenoreceptor-Dependent Mechanism.
Cells - 20 May 2020
Błyszczuk Przemysław, Zuppinger Christian, Costa Ana, Nurzynska Daria, Di Meglio Franca Di, Stellato Mara, Agarkova Irina, Smith Godfrey L, Distler Oliver, Kania Gabriela
Abstract excerpt
Cardiac fibrosis represents a serious clinical problem. Development of novel treatment strategies is currently restricted by the lack of the relevant experimental models in a human genetic context. In this study, we fabricated self-aggregating, scaffold-free, 3D cardiac microtissues using human inducible pluripotent stem cell (iPSC)-derived cardiomyocytes and human cardiac fibroblasts. Fibrotic condition was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.