Article

Dysferlin is a novel regulator of COMP-positive matrifibrocytes in heart failure

2026-08-19

Abstract excerpt

<h4>Background and Aims</h4> Cardiac fibrosis is a major contributor to heart failure (HF), yet mechanisms limiting pathological fibroblast activation remain incompletely understood. We identified dysferlin (DYSF), a membrane repair protein, as highly induced in HF fibroblasts and investigated its role in regulating profibrotic responses. <h4>Methods</h4> Cardiac fibroblasts from patients with end-stage HF and u...

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Literature Corpus work: e4ba5a66-a200-58ce-bb01-347cadafba4b
DOI: 10.64898/2026.08.18.745492

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