Article

The dual PPAR-α/δ agonist elafibranor attenuates TGF-β <sub>1</sub> -induced cardiac fibrosis through redox-metabolic and bioenergetic reprogramming in human cardiac models

2026-08-19

Abstract excerpt

<h4>Background</h4> Cardiac fibrosis drives adverse myocardial remodelling through persistent fibroblast activation, ECM deposition, and impaired cardiac function. Current therapies offer limited protection against cardiac fibrosis progression. Elafibranor is a dual PPAR-α/δ agonist approved for the treatment of liver disease. However, its effects in human models of cardiac fibrosis remain insufficiently explored...

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Literature Corpus work: 44c826bc-076b-5509-a2bd-ba7f8ff415a8
DOI: 10.64898/2026.08.18.745425

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