Integrative multi-omics analysis reveals conserved hierarchical mechanisms of FOXO3 pioneer-factor activity

Abstract excerpt

FOXO transcription factors are critical for cellular homeostasis and have been implicated in longevity in several species. Yet how these factors directly affect aging, particularly in humans, is not well understood. Here, we take an integrated multi-omics approach to identify the chromatin-level mechanisms by which FOXO3 coordinates transcriptional programs. We find that FOXO3 functions as a pioneer factor in huma...

Topics

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• Age Factors
• CCCTC-Binding Factor
• Computer Simulation
• Forkhead Box Protein O3
• FOXO transcription factor regulation
• Genetics, Aging, and Longevity in Model Organisms
• Insulin-Like Growth Factor I
• Longevity

Identifiers and source

Literature Corpus work

b3221466-ab87-51a8-a57d-4c8d0cd5f027

DOI

10.1101/2021.04.06.438676