Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence.

The Journal of biological chemistry - 3 Mar 2017

Jung Hyun-Jung, Byun Hae-Ok, Jee Byul A, Min Seongki, Jeoun Un-Woo, Lee Young-Kyoung, Seo Yonghak, Woo Hyun Goo, Yoon Gyesoon

Abstract excerpt

As senescence develops, cells sequentially acquire diverse senescent phenotypes along with simultaneous multistage gene reprogramming. It remains unclear what acts as the key regulator of the collective changes in gene expression at initiation of senescent reprogramming. Here we analyzed time series gene expression profiles obtained in two different senescence models in human diploid fibroblasts: replicative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to CCAAT-Enhancer-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Chromobox Protein Homolog 5

Share to DNA (Cytosine-5-)-Methyltransferase 1

Share to DNA (Cytosine-5-)-Methyltransferases

Share to Hydrogen Peroxide

Share to Wnt-5a Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 28100769
DOI: 10.1074/jbc.M116.750539
PMCID: PMC5339756

Genes

DNMT1
UHRF1
CBX5
CHEK1
HELLS
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Ubiquitin-like with PHD and Ring Finger Domains 1 (UHRF1)/DNA Methyltransferase 1 (DNMT1) Axis Is a Primary Regulator of Cell Senescence.PMID 28100769Read ↗

Epigenetic Regulation of Cellular SenescenceSemantic proximity Read ↗

Evolutionary and Functional Roles of DNA Methylation in Human Senescence RegulationSemantic proximity Read ↗

Integrated multi-omics approach revealed cellular senescence landscapeSemantic proximity Read ↗

UHRF1 is required for basal stem cell proliferation in response to airway injurySemantic proximity Read ↗

Single-Cell RNA-Seq Analysis Reveals Four Stages of Replicative Senescence in Human Umbilical Vein Endothelial CellsSemantic proximity Read ↗

Interrogating the regulatory epigenome of cellular senescenceSemantic proximity Read ↗

The Histone Code of Senescence.Semantic proximity Read ↗

Broad repression of DNA repair genes in senescent cells identified by integration of transcriptomic dataSemantic proximity Read ↗

UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma.Semantic proximity Read ↗

Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescenceSemantic proximity Read ↗

Epigenetic Reprogramming of Aging: Reversing the Clock for Regenerative MedicineSemantic proximity Read ↗

Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.