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Article

Downregulation of MLF1 safeguards cardiomyocytes against senescence-associated chromatin opening

9 Dec 2024

Abstract excerpt

Aging-associated cardiac hypertrophy (AACH) increases susceptibility to heart failure in the elderly. Chromatin remodeling contributes to the gene reprogramming in AACH; however, the intrinsic regulations remain elusive. We performed a transcriptome analysis for AACH in comparison with pressure-overload-induced pathological cardiac hypertrophy in mice and identified myeloid leukemia factor 1 (MLF1) as an...

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PMID: 39657728
DOI: 10.1093/nar/gkae1176

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