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A single gp120 residue can affect HIV-1 tropism in macaques

25 Sept 2017

Abstract excerpt

Species-dependent variation in proteins that aid or limit virus replication determines the ability of lentiviruses to jump between host species. Identifying and overcoming these differences facilitates the development of animal models for HIV-1, including models based on chimeric SIVs that express HIV-1 envelope (Env) glycoproteins, (SHIVs) and simian-tropic HIV-1 (stHIV) strains. Here, we demonstrate that the...

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PMID: 28945790
DOI: 10.1371/journal.ppat.1006572

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