A species-specific amino acid difference in the macaque CD4 receptor restricts replication by global circulating HIV-1 variants representing viruses from recent infection.

Abstract excerpt

HIV-1 replicates poorly in macaque cells, and this had hindered the advancement of relevant nonhuman primate model systems for HIV-1 infection and pathogenesis. Several host restriction factors have been identified that contribute to this species-specific restriction to HIV-1 replication, but these do not fully explain the poor replication of most strains of HIV-1 in macaque cells. Only select HIV-1 envelope...

Topics

• Amino Acid Substitution
• Animals
• CD4 Antigens
• Cell Line
• DNA Primers
• Disease Models, Animal
• Evolution, Molecular
• Genetic Variation
• Green Fluorescent Proteins
• HIV Infections