Article

Pol II degradation activates cell death independently from the loss of transcription

2024-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Pol II-mediated transcription is essential for eukaryotic life. While loss of transcription is thought to be universally lethal, the associated mechanisms promoting cell death are not yet known. Here, we show that death following loss of Pol II is not caused by dysregulated gene expression. Instead, death occurs in response to the loss of Pol II protein itself, specifically loss of the enzymatic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a98f40a-f090-5279-bf9f-004d1a011286
DOI: 10.1101/2024.12.09.627542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pol II degradation activates cell death independently from the loss of transcriptionDOI 10.1101/2024.12.09.627542Read

Therapeutic Targeting of the General RNA Polymerase II Transcription MachinerySemantic proximity Read

Coordination of transcription-coupled repair and repair-independent release of stalled RNA polymerase II in response to transcription-blocking lesionsSemantic proximity Read

Drugging the Cancers Addicted to DNA RepairSemantic proximity Read

Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers.Semantic proximity Read

P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathwaySemantic proximity Read

Proteogenomic discovery of <i>RB1</i> -defective phenocopy in cancer predicts disease outcome, response to treatment, and therapeutic targetsSemantic proximity Read

The general transcription factor TFIIB is a target for transcriptome control during cellular stress and viral infectionSemantic proximity Read

Regulation and Modulation of Human DNA Polymerase δ Activity and FunctionSemantic proximity Read

Chemical exhaustion of RPA in cancer treatmentSemantic proximity Read

A cancer-associated RNA polymerase III identity drives robust transcription and expression of SNAR-A noncoding RNASemantic proximity Read

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase IISemantic proximity Read

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivitySemantic proximity Read