Article

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbation

2025-09-18

Abstract excerpt

Transcription is regulated by sequence-specific transcription factors and enzymes allowing access to genes in chromatin. However, recent data indicate that the abundance of RNA polymerase II (RNAPII) itself may under certain circumstances represent an additional, crucial determinant of transcription regulation. Here, we used the dTAG system to titrate the cellular dosage of human RPB1, the largest RNAPII subunit,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a0c151d-5431-560d-99c9-601213e39488
DOI: 10.1101/2025.09.18.677100

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systems-level feedback loops maintain gene expression homeostasis following RNA polymerase II dosage perturbationDOI 10.1101/2025.09.18.677100Read

Multi-timescale PTM architecture in human RNA polymerase IISemantic proximity Read

Therapeutic Targeting of the General RNA Polymerase II Transcription MachinerySemantic proximity Read

The general transcription factor TFIIB is a target for transcriptome control during cellular stress and viral infectionSemantic proximity Read

Crosstalk between mRNA 3' end processing and transcription initiation.Semantic proximity Read

Transcription directionality is licensed by Integrator at active human promotersSemantic proximity Read

Gene dosage imbalances: action, reaction, and models.Semantic proximity Read

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcriptionSemantic proximity Read

RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast.Semantic proximity Read

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcriptionSemantic proximity Read

High-resolution mapping of human RNA polymerase III reveals transcription termination as a rate-limiting stepSemantic proximity Read

RNA Pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD Phosphorylation, and Transcriptional Direction.Semantic proximity Read

SPT5 stabilizes RNA polymerase II, orchestrates transcription cycles, and maintains the enhancer landscape.Semantic proximity Read