Article

Kaposi’s Sarcoma-associated herpesvirus uses a novel protein fold to hijack RNA Polymerase II for viral late gene transcription

2026-06-29

Abstract excerpt

Herpesviruses, including the oncogenic human pathogen Kaposi’s Sarcoma-associated herpesvirus (KSHV), rely on cellular RNA Polymerase II (RNAPII) for expression of their protein-coding genes. Late in the lytic cycle, transcription initiation on a subset of KSHV genes depends on ORF24, a viral transcriptional activator that binds to viral late promoters through structural mimicry of a host transcription factor. Her...

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Literature Corpus work: aef069f1-b764-5d55-a6de-05acddfb85b9
DOI: 10.64898/2026.06.29.734287

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