Article
Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor.
Nature - 1 Apr 2018
Yang Zhenlin, Han Shuo, Keller Max, Kaiser Anette, Bender Brian J, Bosse Mathias, Burkert Kerstin, Kögler Lisa M, Wifling David, Bernhardt Guenther, Plank Nicole, Littmann Timo, Schmidt Peter, Yi Cuiying, Li Beibei, Ye Sheng, Zhang Rongguang, Xu Bo, Larhammar Dan, Stevens Raymond C, Huster Daniel, Meiler Jens, Zhao Qiang, Beck-Sickinger Annette G, Buschauer Armin, Wu Beili
Abstract excerpt
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology 1,2 . The NPY-Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y1, Y2, Y4 and Y5 receptors, with different affinity and...
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