Article

Development of novel allosteric regulators of proteinase-activated receptors

2019-01-01

Abstract excerpt

Proteinase-activated receptors (PARs), members of the G-protein coupled receptor (GPCR) superfamily of proteins, represent highly attractive targets for therapy across a wide range of diseases. Of specific interest are PAR1 and PAR2, the major signalling members of the PAR family which are associated with cardiovascular disease, cancer and inflammatory disease. However, despite significant efforts, there is only o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fbe8b0f6-b179-57d0-abc1-a713a87bac96
DOI: 10.48730/cb57-ar16

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of novel allosteric regulators of proteinase-activated receptorsDOI 10.48730/cb57-ar16Read

Protease‐activated receptor 4: from structure to function and back againSemantic proximity Read

The protease activated receptor 2 (PAR2) polymorphic variant F240S constitutively activates PAR2 receptors and potentiates responses to small-molecule PAR2 agonists.Semantic proximity Read

Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4).Semantic proximity Read

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.Semantic proximity Read

Diversification of PAR signaling through receptor crosstalkSemantic proximity Read

Proteinase-Activated Receptor 2 (PAR2) Deficiency and Cardiovascular Regulation: Context-Dependent Effects on Inflammation and FibrosisSemantic proximity Read

Protease-Activated Receptors in the Intestine: Focus on Inflammation and CancerSemantic proximity Read

Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling.Semantic proximity Read

Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): PAR-2 as a Potential Therapeutic TargetSemantic proximity Read

Autocrine Proteinase Activated Receptor (PAR) mediated signaling in prostate cancer cellsSemantic proximity Read

Targeting formyl peptide receptors to facilitate the resolution of inflammationSemantic proximity Read

Protease-Activated Receptor 1 as an Endogenous Model of Peptidergic Gαq-Gα12-Biased G Protein SignalingSemantic proximity Read