Article

TGFβ-dependent upregulation of OCIAD2 is essential for epithelial-to-mesenchymal transition during mesendoderm differentiation

2025-11-11

Abstract excerpt

<h4>Summary</h4> Deciphering mechanisms that govern lineage commitment of human pluripotent stem cells (hPSCs) is essential for optimizing differentiation strategies. Here, we investigated the role of the mitochondrial protein OCIAD2 in hPSC differentiation. We show that OCIAD2 is transiently upregulated during mesendoderm differentiation, in a TGFβ/Activin A-dependent manner. OCIAD2 depletion impairs mesendoderm...

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Literature Corpus work: 50ae762c-50e6-51e5-856c-6a4cad600f9e
DOI: 10.1101/2025.11.10.687537

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TGFβ-dependent upregulation of OCIAD2 is essential for epithelial-to-mesenchymal transition during mesendoderm differentiationDOI 10.1101/2025.11.10.687537Read

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