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Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signaling

16 Apr 2025

Abstract excerpt

Metabolic pathways can influence cell fate decisions, yet their regulative role during embryonic development remains poorly understood. Here, we demonstrate an instructive role of glycolytic activity in regulating signaling pathways involved in mesoderm and endoderm specification. Using a mouse embryonic stem cell (mESC)-based in vitro model for gastrulation, we found that glycolysis inhibition increases...

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PMID: 40245870
DOI: 10.1016/j.stem.2025.03.011

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