Article

Spatial transcriptome profiling uncovers metabolic regulation of left-right patterning

2023-04-21

Abstract excerpt

Left-right patterning disturbance can cause severe birth defects, but it remains least understood of the three body axes. We uncovered an unexpected role for metabolic regulation in left-right patterning. Analysis of the first spatial transcriptome profile of left-right patterning revealed global activation of glycolysis, accompanied by right-sided expression of Bmp7 and genes regulating insulin growth factor sig...

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Literature Corpus work: bd53d051-4565-5539-8bc5-53b3f9212b96
DOI: 10.1101/2023.04.21.537827

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