Article

Circulating plasma microRNAs miR-150 and miR-375 levels are associated with age-related endotypes of newly diagnosed Type 1 Diabetes

2026-02-24

Abstract excerpt

Age-defined type 1 diabetes (T1D) endotypes, T1DE1 and T1DE2, are characterized by reproducible differences in pancreatic immunopathology and clinical course. In particular, these endotypes differ in the extent and composition of lymphocytic insulitis and in the extent of loss of insulin-producing β cell mass, at diagnosis. However, blood-based biomarkers that may distinguish these endotypes and inform the underly...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e3b56a78-23ec-5bf2-abfa-03902b537737
DOI: 10.64898/2026.02.18.26346540

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Circulating plasma microRNAs miR-150 and miR-375 levels are associated with age-related endotypes of newly diagnosed Type 1 DiabetesDOI 10.64898/2026.02.18.26346540Read

Title: β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes RiskSemantic proximity Read

Human immune phenotyping reveals accelerated aging in type 1 diabetesSemantic proximity Read

Cell type–specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetesSemantic proximity Read

A microRNA-based dynamic risk score for type 1 diabetesSemantic proximity Read

Insights From Single Cell RNA Sequencing Into the Immunology of Type 1 Diabetes- Cell Phenotypes and Antigen Specificity.Semantic proximity Read

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onsetSemantic proximity Read

Systematic immune cell dysregulation and molecular subtypes revealed by single-cell RNA-seq of subjects with type 1 diabetesSemantic proximity Read

Precision Diagnostics: Using Islet Autoantibodies to Characterize Heterogeneity in Type 1 DiabetesSemantic proximity Read

Aberrant immune regulation and enrichment of stem-like CD8 <sup>+</sup> T cells in the pancreatic lymph node during type 1 diabetes developmentSemantic proximity Read

Circulating MicroRNAs as Predictors of Beta Cell Function in Youth-onset Type 2 Diabetes: The TODAY StudySemantic proximity Read

Dynamic Immune Phenotypes of B and T Helper Cells Mark Distinct Stages of T1D ProgressionSemantic proximity Read

An imbalance of naïve and effector T-cell phenotypes in early type 1 diabetes across conventional and regulatory subsetsSemantic proximity Read