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A microRNA-based dynamic risk score for type 1 diabetes

5 Jun 2025

Abstract excerpt

Identifying individuals at high risk of type 1 diabetes (T1D) is crucial as disease-delaying medications are available. Here we report a microRNA (miRNA)-based dynamic (responsive to the environment) risk score developed using multicenter, multiethnic and multicountry ('multicontext') cohorts for T1D risk stratification. Discovery (wet and dry lab) analysis identified 50 miRNAs associated with functional β cell...

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PMID: 40473952
DOI: 10.1038/s41591-025-03730-7

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