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Article

Cell type–specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes

20 Feb 2019

Abstract excerpt

The rate of decline in insulin secretion after diagnosis with type 1 diabetes (T1D) varies substantially among individuals and with age at diagnosis, but the mechanism(s) behind this heterogeneity are not well understood. We investigated the loss of pancreatic β cell function in new-onset T1D subjects using unbiased whole blood RNA-seq and verified key findings by targeted cell count measurements. We found that...

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PMID: 30830868
DOI: 10.1172/jci.insight.125556

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