Article

Pharmacological inhibition of longevity regulator PAPP-A restrains mesenchymal stromal cell activity

2020-02-06

Abstract excerpt

Reducing insulin-like growth factor (IGF) signaling is one of the best conserved and characterized mechanisms to extend longevity. Pregnancy associated plasma protein A (PAPP-A) is a secreted metalloprotease that increases IGF availability by cleaving IGF binding proteins. PAPP-A inhibition reduces local IGF signaling, limits the progression of multiple age-related diseases, and extends lifespan, but the mechanism...

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Literature Corpus work: aa68d727-c8bb-55bf-b973-ede5c2256103
DOI: 10.1101/2020.02.05.936310

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