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Article

PAPP-A2 expression by osteoblasts is required for normal postnatal growth in mice.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Dec 2015

Amiri Neilab, Christians Julian K

Abstract excerpt

OBJECTIVE: Pregnancy associated plasma protein-A2 (PAPP-A2) is a protease that cleaves insulin-like growth factor binding protein-5 (IGFBP-5), the most abundant IGFBP in bone. Deletion of Pappa2 reduces postnatal growth and bone length in mice. The aim of this study was to determine whether locally produced PAPP-A2 is required for normal bone growth. DESIGN: We deleted Pappa2 primarily in osteoblasts by crossing...

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Identifiers

PMID: 26385171
DOI: 10.1016/j.ghir.2015.09.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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