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Article

Pregnancy-Associated Plasma Protein (PAPP)-A2 in Physiology and Disease.

Cells - 18 Dec 2021

Barrios Vicente, Chowen Julie A, Martín-Rivada Álvaro, Guerra-Cantera Santiago, Pozo Jesús, Yakar Shoshana, Rosenfeld Ron G, Pérez-Jurado Luis A, Suárez Juan, Argente Jesús

Abstract excerpt

The growth hormone (GH)/insulin-like growth factor (IGF) axis plays fundamental roles during development, maturation, and aging. Members of this axis, composed of various ligands, receptors, and binding proteins, are regulated in a tissue- and time-specific manner that requires precise control that is not completely understood. Some of the most recent advances in understanding the implications of this axis in...

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Identifiers

PMID: 34944082
DOI: 10.3390/cells10123576
PMCID: PMC8700087

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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