Article

WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm

2025-06-08

Abstract excerpt

<h4>Summary</h4> Human pluripotent stem cells (hPSCs) can be used as a scalable source of lymphocytes for adoptive cell therapies, contingent on the robust generation of definitive hematopoietic intermediates. Early WNT activation with CHIR99021 during mesoderm induction promoted the formation of KDR+ ALDH1A2+ mesodermal progenitors and subsequent generation of T cells in a retinoic acid (RA)-dependent manner. In...

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Literature Corpus work: e38073bd-5336-5463-aff9-9d1b7d0e3a4e
DOI: 10.1101/2025.06.06.657928

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