Article
Targeting histone acetylation enables epigenetic modulation of inflammatory pathways – a novel therapeutic strategy for rheumatoid arthritis
2025-01-18
Abstract excerpt
Autoimmune diseases like rheumatoid arthritis (RA) are characterized by a systemic inflammation caused by autoreactive immune cells. Epigenomic modulation of these cells offers a strategy to reprogram pathogenic pathways without altering the genome, potentially restoring immune balance. Epigenetic inhibitors are already utilized in oncology but often exhibit adverse effects due to lack of selectivity and cytotoxic...
Topics
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- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Histone Deacetylase Inhibitors Research
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
Identifiers and source
- Literature Corpus work
- 3d5058fa-8522-5232-a8a2-60f9b1713fe2
- DOI
- 10.1101/2025.01.14.632975