Article

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells

2021-03-17

Abstract excerpt

Variability between human pluripotent stem cell (hPSC) lines remains a challenge and opportunity in biomedicine. We identified differences in the early lineage emergence across hPSC lines that mapped on the antero-posterior axis of embryonic development. RNA-seq analysis revealed dynamic transcriptomic patterns that defined the emergence of mesendodermal versus neuroectodermal lineages conserved across hPSC lines...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66f103b4-7a60-58ee-bf9e-0ca62a03e550
DOI: 10.1101/2021.03.17.435870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cellsDOI 10.1101/2021.03.17.435870Read

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem CellsSemantic proximity Read

Single-cell RNA-seq reveals dynamic transcriptome profiling in human early neural differentiationSemantic proximity Read

RAI1 safeguards fidelity and tempo of human neurodevelopmental gene expressionSemantic proximity Read

Multi-omics analysis reveals a crucial role for Retinoic Acid in promoting epigenetic and transcriptional competence of an in vitro model of human Pharyngeal EndodermSemantic proximity Read

Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotencySemantic proximity Read

Generation, selection and transcriptomic profiling of human neuromesodermal and spinal cord progenitors in vitroSemantic proximity Read

Single cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiationSemantic proximity Read

Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterningSemantic proximity Read

Single-cell RNA-seq analysis of human iPSC-derived motor neurons resolves early and predictive ALS signaturesSemantic proximity Read

Midbrain Dopaminergic Neuron Development is Regulated by Two Molecularly Distinct Subtypes of Radial Glia CellsSemantic proximity Read

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain developmentSemantic proximity Read

Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fatesSemantic proximity Read