Article

N <sup>6</sup> -Methyladenosine Safeguards Mouse and Human Germline Competence

2025-11-18

Abstract excerpt

N 6 -Methyladenosine (m 6 A) regulation of germline entry in post-implantation-like-pluripotent states remains poorly defined. We characterized m 6 A depletion by Mettl3 or Mettl14 knock-down or METTL3 inhibition in in vitro models enabling primordial germ-cell-like-cell and somatic differentiation. Upon m 6 A depletion, mouse epiblast-like cells upregulated embryonic Ras (Eras) and PI3K-pAKT, facilitating...

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Literature Corpus work: 4bc65163-1db9-5c9a-9d8c-fc2c2335dc18
DOI: 10.1101/2025.11.18.688769

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