Article
Structural mechanism of mitochondrial membrane remodelling by human OPA1.
Nature - 1 Aug 2023
von der Malsburg Alexander, Sapp Gracie M, Zuccaro Kelly E, von Appen Alexander, Moss Frank R, Kalia Raghav, Bennett Jeremy A, Abriata Luciano A, Dal Peraro Matteo, van der Laan Martin, Frost Adam, Aydin Halil
Abstract excerpt
Distinct morphologies of the mitochondrial network support divergent metabolic and regulatory processes that determine cell function and fate1-3. The mechanochemical GTPase optic atrophy 1 (OPA1) influences the architecture of cristae and catalyses the fusion of the mitochondrial inner membrane4,5. Despite its fundamental importance, the molecular mechanisms by which OPA1 modulates mitochondrial morphology are...
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