Article

Structural Basis for Regulated Assembly of the Mitochondrial Fission GTPase Drp1

2023-06-22

Abstract excerpt

Mitochondrial fission is crucial for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation. This multistep process is initiated by the enhanced recruitment and oligomerization of dynamin-related protein 1 (Drp1) at the surface of mitochondria. As such, Drp1 is essential for inducing mitochondrial division in mammalian cells, and homologou...

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Literature Corpus work: 4906e7c3-2d37-5f9f-a11e-3664aa50ae0a
DOI: 10.1101/2023.06.22.546081

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