Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution.

Cell death & disease - 30 Nov 2024

Macuada J, Molina-Riquelme I, Vidal G, Pérez-Bravo N, Vásquez-Trincado C, Aedo G, Lagos D, Yu-Wai-Man P, Horvath R, Rudge T J, Cartes-Saavedra B, Eisner V

Abstract excerpt

Optic atrophy protein 1 (OPA1) mediates inner mitochondrial membrane (IMM) fusion and cristae organization. Mutations in OPA1 cause autosomal dominant optic atrophy (ADOA), a leading cause of blindness. Cells from ADOA patients show impaired mitochondrial fusion, cristae structure, bioenergetic function, and mitochondrial DNA (mtDNA) integrity. The mtDNA encodes electron transport chain subunits and is packaged...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to OPA1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Mitochondria

Share to Mutation

Share to Optic Atrophy, Autosomal Dominant

Source

Open in PubMed Open full text

Identifiers

PMID: 39616197
DOI: 10.1038/s41419-024-07165-9
PMCID: PMC11608329

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution.PMID 39616197Read ↗

<i>OPA1</i> and disease-causing mutants perturb mitochondrial nucleoid distributionSemantic proximity Read ↗

Mitochondrial dynamics and disease, OPA1.Semantic proximity Read ↗

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion.Semantic proximity Read ↗

Structural mechanism of mitochondrial membrane remodelling by human OPA1.Semantic proximity Read ↗

Mitochondrial oxidative phosphorylation in autosomal dominant optic atrophy.Semantic proximity Read ↗

Changes in Mitochondrial Morphology and Bioenergetics in Human Lymphoblastoid Cells With Four Novel OPA1 Mutations.Semantic proximity Read ↗

OPA1 (dys)functions.Semantic proximity Read ↗

Mitochondrial optic neuropathies: how two genomes may kill the same cell type?Semantic proximity Read ↗

OPA1: How much do we know to approach therapy?Semantic proximity Read ↗

OPA1 helical structures give perspective to mitochondrial dysfunction.Semantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and DiseaseSemantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.