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Article

OPA1: How much do we know to approach therapy?

Pharmacological research - 1 May 2018

Del Dotto Valentina, Fogazza Mario, Lenaers Guy, Rugolo Michela, Carelli Valerio, Zanna Claudia

Abstract excerpt

OPA1 is a GTPase that controls several functions, such as mitochondrial dynamics and energetics, mtDNA maintenance and cristae integrity. In the last years, there have been described other cellular pathways and mechanisms involving OPA1 directly or through its interaction. All this new information, by implementing our knowledge on OPA1 is instrumental to elucidating the pathogenic mechanisms of OPA1 mutations....

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Share to DNA, Mitochondrial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Optic Atrophy, Autosomal Dominant

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Source

Identifiers

PMID: 29454676
DOI: 10.1016/j.phrs.2018.02.018

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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