Article

Allo-defensive, multiplex base-edited, anti-CD38 CAR T cells for ‘off-the-shelf’ Immunotherapy

2025-08-24

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapies are being widely investigated in both autologous and allogeneic settings, with gene editing providing new strategies to address barriers to mismatched cell therapies. Currently ‘universal’ donor derived T cell therapies require intensive lymphodepletion and are prone to host-mediated rejection. CD38, a transmembrane glycoprotein involved in cell activation and bioen...

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Literature Corpus work: e345bd54-b488-5c49-bee9-2a282f20a3ba
DOI: 10.1101/2025.08.20.671266

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