Genome-edited allogeneic donor “universal” chimeric antigen receptor T cells

doi:10.1182/blood.2022016204

Article

Genome-edited allogeneic donor “universal” chimeric antigen receptor T cells

12 Oct 2022

Abstract excerpt

αβ T cell receptor (TCRαβ) T cells modified to express chimeric antigen receptors (CAR), are now available as authorized therapies for certain B-cell malignancies. However the process of autologous harvest and generation of patient-specific products is costly, with complex logistics and infrastructure requirements. Premanufactured banks of allogeneic donor-derived CAR T cells could help widen applicability if the...

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