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Article

Allogeneic CAR-T Cells: Engineering Around Host Immunity

2025-12-22

Abstract excerpt

Allogeneic (“off-the-shelf”) CAR-T cells promise faster treatment access, standardized manufacturing, and scalable supply compared with autologous products, but they face a core biological constraint: the recipient immune system recognizes allogeneic CAR-T as a graft and eliminates it, while residual donor T-cell receptor (TCR) activity can cause graft-versus-host disease (GvHD). Clinical progress over the last se...

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Literature Corpus work
d74a04fb-c93b-5ee3-b13d-cbb6059d916c
DOI
10.20944/preprints202512.1835.v1
Open publication

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Allogeneic CAR-T Cells: Engineering Around Host ImmunityDOI 10.20944/preprints202512.1835.v1
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