Article

Universal protection of allogeneic cell therapies from natural killer cells via CD300a agonism

2024-05-07

Abstract excerpt

Immunogenicity limits the persistence of off-the-shelf, allogeneic cell therapies and transplants. While ablation of human leukocyte antigen (HLA) removes most T cell and humoral alloreactivity, no solution has enabled universal protection against the resulting natural killer (NK) cell response. Here, we engineered Trans Antigen Signaling Receptors (TASR) as a new class of NK inhibitory ligands and discovered CD30...

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Literature Corpus work: fbc6c641-3729-5c48-a293-1853394596f9
DOI: 10.1101/2024.05.05.592600

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