Article

A differentiated and durable allogeneic strategy applicable to cell therapies

2025-04-01

Abstract excerpt

Autologous T cell therapies have shown profound clinical responses; however, their widespread use has been limited primarily due to their individualized manufacturing requirements. To develop a persistent "off-the-shelf" allogeneic (Allo) approach, a multiplex Nme2Cas9-based cytosine base editor was deployed to knockout select HLA Class I and II alleles ( HLA-A , HLA-B , and the class II transactivator ( CIITA...

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Literature Corpus work: ef44d36a-bf9a-5c40-8a9f-fe164269603c
DOI: 10.1101/2025.03.27.645807

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