Article

Endowing Universal CAR T-cell with Immune-Evasive Properties using TALEN-Gene Editing

2021-12-06

Abstract excerpt

Universal CAR T-cell therapies are poised to revolutionize cancer treatment and to improve patient outcomes. However, realizing these advantages in an allogeneic setting requires universal CAR T-cells that can kill target tumor cells, avoid depletion by the host immune system, and proliferate without attacking host tissues. Here, we describe the development of a novel immune-evasive CAR T-cells scaffold that evade...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aa4c353e-64f2-5f4f-8273-458af74a5ec4
DOI: 10.1101/2021.12.06.471451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Endowing Universal CAR T-cell with Immune-Evasive Properties using TALEN-Gene EditingDOI 10.1101/2021.12.06.471451Read

Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editingSemantic proximity Read

Unleashing the Therapeutic Potential of CAR-T Cell Therapy Using Gene-Editing Technologies.Semantic proximity Read

Genome Editing in Engineered T Cells for Cancer ImmunotherapySemantic proximity Read

Engineering allorejection-resistant CAR-NKT cells from hematopoietic stem cells for off-the-shelf cancer immunotherapySemantic proximity Read

Engineering the next-generation of CAR T-cells with CRISPR-Cas9 gene editingSemantic proximity Read

Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapySemantic proximity Read

A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapiesSemantic proximity Read

Explorations of CRISPR/Cas9 for improving the long-term efficacy of universal CAR-T cells in tumor immunotherapySemantic proximity Read

Comprehensive genome editing confers ‘off-the-shelf’ CAR-T cells superior efficacy against solid tumorsSemantic proximity Read

CRISPR/Cas9 revitalizes adoptive T-cell therapy for cancer immunotherapySemantic proximity Read

Delivery technologies for T cell gene editing: Applications in cancer immunotherapySemantic proximity Read

Using Gene Editing Approaches to Fine-Tune the Immune SystemSemantic proximity Read