Article

Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice

2026-01-12

Abstract excerpt

The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic, being associated with both Parkinson’s disease (PD) and Crohn’s disease (CD). Coding variants associated with risk of PD and CD act as gain of function kinase mutations increasing phosphorylation of RAB substrates, and non-coding variants in the promoter region of LRRK2 increase expression of the gene, notably in im...

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Literature Corpus work: e332438f-c488-5833-ab33-4bbc9b79c0d6
DOI: 10.64898/2026.01.11.698894

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