Article

Proteasome-dependent degradation of histone H1 subtypes is mediated by its C-terminal domain

2023-06-18

Abstract excerpt

Histone H1 is involved in chromatin compaction and dynamics. In human cells, the H1 complement is formed by different amounts of somatic H1 subtypes, H1.0-H1.5 and H1X. The amount of each variant depends on the cell type, the cell cycle phase, and the time of development and can be altered in disease. However, the mechanisms regulating H1 protein levels have not been described. We have analyzed the contribution of...

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Literature Corpus work: e32bc2aa-8728-5f0e-99e3-37f40ea4521a
DOI: 10.1101/2023.06.17.545431

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