Article

Cocaine exacerbates neurological impairments and neuropathologies in the iTat model of HIV-associated neurocognitive disorder through genome-wide alterations of DNA methylation and gene expression

2021-11-24

Abstract excerpt

<h4>ABSTRACT</h4> HIV infection of the central nervous system causes HIV-associated neurocognitive disease (HAND) in up to 50% HIV-infected individuals. Cocaine use is prevalent in the HIV-infected population and has been shown to facilitate the HAND progression. However, the cellular and molecular mechanism of the cocaine-facilitated HAND progression remains largely unknown. In this study, we took advantage of t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 79e6c9ae-345a-50ed-adcd-9b6864c0df41
DOI: 10.1101/2021.11.22.469603

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cocaine exacerbates neurological impairments and neuropathologies in the iTat model of HIV-associated neurocognitive disorder through genome-wide alterations of DNA methylation and gene expressionDOI 10.1101/2021.11.22.469603Read

The Genetic Fingerprint of HIV in the Brain: Insights into Neurocognitive DysfunctionSemantic proximity Read

Long-term HIV-1 Tat Expression in the Brain Led to Neurobehavioral, Pathological, and Epigenetic Changes Reminiscent of Accelerated AgingSemantic proximity Read

Neurological impact of HIV/AIDS and substance use alters brain function and structureSemantic proximity Read

Genome-wide association study of HIV-associated neurocognitive disorder (HAND): A CHARTER group study.Semantic proximity Read

Genomic Factors and Therapeutic Approaches in HIV-Associated Neurocognitive Disorders: A Comprehensive ReviewSemantic proximity Read

HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylationSemantic proximity Read

Epigenetic editing of Cartpt promotes acquisition and extinction of cocaine memorySemantic proximity Read

Transcriptomic analysis of brain tissues identifies a role for CCAAT enhancer binding protein β in HIV-associated neurocognitive disordersSemantic proximity Read

HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorderSemantic proximity Read

Epigenetic Alterations in the Brain Associated with HIV-1 Infection and Methamphetamine DependenceSemantic proximity Read

Host genetic factors predisposing to HIV-associated neurocognitive disorder.Semantic proximity Read

HIV-1 Tat protein exposure alters the morphological characteristics and gene expression in the primary mouse cortex endothelial cells and human brain microvascular endothelial cellsSemantic proximity Read