Article

The G256E HCM mutation prolongs relaxation via altered nucleotide handling

2025-09-04

Abstract excerpt

Mutations in myosin alter its motor functions in diverse ways by affecting different structural and chemo-mechanical events. Multidisciplinary strategies can be used to understand how varying alterations in motor function converge to common phenotypes like hypercontractility and hypertrophic cardiomyopathy (HCM). Here, we combined molecular dynamics (MD) simulations with protein biochemical and myofibril mechanica...

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Literature Corpus work: cd09c70f-86d8-5cbc-acf6-ad9bae911ebc
DOI: 10.1101/2025.08.29.673178

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